Change of https://www.gov.uk/government/publications/hexavalent-combination-vaccine-programme-guidance

Change description : 2025-12-17 11:30:00: Updated to include new training slides for download and updates to the main guidance document to reflect the introduction of MMRV to the routine schedule for children from 1 January 2026 [Guidance and regulation]

Showing diff : 2025-06-02 13:01:06.646728375 +00:00..2025-12-17 11:30:21.444315972 +00:00

Guidance

Hexavalent combination vaccine: programme guidance

Guidance for healthcare practitioners on the hexavalent vaccine programme, including its use in the selective neonatal hepatitis B programme, from 1 July 2025. programme.

From:
UK Health Security Agency
Published
5 July 2017
Last updated
217 JuneDecember 2025 — See all updates

Applies to England

Documents

Hexavalent DTaP/IPV/Hib/HepB combination vaccine: information for healthcare practitioners

HTML

Appendix A: the number of hepatitis-B containing vaccine doses for children – text version

HTML

Appendix A: the number of hepatitis-B containing vaccine doses for children flowchart

PDF, 290 KB, 1 page

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Details

Download the training slide set for healthcare professionals

All babies born on or after 1 August 2017 are eligible for the hexavalent vaccine, which includes hepatitis B (HepB),(HepB), for their primary immunisations. From July 2025, the routine childhood immunisation schedule changed, and children born on or after 1 July 2024 will receive an additional hexavalent vaccine at 18 months of age. The selective neonatal hepatitis B pathway for children born to women with hepatitis B was also amended.

This guidance is aimed at healthcare practitioners involved in the programme and provides information about the hexavalent vaccines ( Vaxelis® and Infanrix hexa®), including information on the changes, eligibility, scheduling and vaccine administration. Separate information for healthcare practitioner guidance, specifically covering the changes to the routine childhood schedule from 1 July 2025,2025 and January 2026, is also available.

More information on the childhood changes to the vaccination schedule

Updates to this page

Published 5 July 2017
Last updated 217 JuneDecember 2025 + show all updates

  2. Updates made to the guidance for healthcare practitioners relating to the changes to the childhood schedule from 1 July 2025. Additional appendix A added.

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Update history

2026-08-26 11:43
Updated to reflect that changes to the childhood programme have been in place for a year, DOB based cohorts have been updated for clarity

2025-12-17 11:30
Updated to include new training slides for download and updates to the main guidance document to reflect the introduction of MMRV to the routine schedule for children from 1 January 2026

2025-06-02 14:01
Updates made to the guidance for healthcare practitioners relating to the changes to the childhood schedule from 1 July 2025. Additional appendix A added.

2025-05-29 14:32
Added new slide set which includes all the changes to the childhood vaccination programme.

2024-05-13 09:30
Added updated guidance and training slide set.

2023-05-18 16:33
Updated information on incomplete or uncertain vaccination histories and stability of Vaxelis.